Skip to main content

Table 1 ICA-induced 8 shared differential metabolites

From: Icariin protects against cage layer osteoporosis by intervening in steroid biosynthesis and glycerophospholipid metabolism

No. Metabolite Rt (s) m/z CON vs. LCD ICA2 vs. LCD
VIP Fold change P-value VIP Fold change P-value
1 7-Dehydrocholesterol 36.177 385.3441977 1.59 2.94 0.003 1.88 2.26 <0.001
2 7-Oxocholesterol 34.835 401.339414 1.61 6.74 0.008 1.86 3.59 0.002
3 Desmosterol 36.73 367.3338581 1.54 3.11 0.008 1.75 2.09 0.003
4 PC (18:1(9Z)/18:1(9Z)) 125.466 824.5521835 1.52 1.51 <0.001 1.84 1.48 <0.001
5 PS (18:0/18:1(9Z)) 132.1485 788.5423368 1.62 1.84 0.002 2.15 1.78 <0.001
6 N,N-Dimethylaniline 36.52 281.1373045 1.53 1.86 <0.001 1.65 1.87 0.030
7 2-hydroxy-butanoic acid 179.823 103.0396129 1.63 2.01 0.002 1.78 1.51 0.005
8 N2,N2-Dimethylguanosine 180.198 310.1146027 1.76 0.48 <0.001 1.79 0.58 0.003
  1. Notes: Only metabolites with a variable importance projection (VIP) value greater than 1.5 and a P-value less than 0.05 were selected as differential metabolites. ICA, icariin. CON, basal diet. LCD, low calcium diet. ICA2, low calcium diet supplied with 2.0 g/kg ICA