Table 1 Summary of bile acids on the replication of enteric viruses
Viruses | Major virus replication sites (D, J, I, or C) in vivo | In vitro cell line | Name of BAs (concentration tested) | References | ||
|---|---|---|---|---|---|---|
Pro-viral | Anti-viral | No effects | ||||
PoSaV/GIII/Cowden strain (or PEC) | D, J | LLC-PK1 | GCA (50–500 μM), GCDCA (50–500 μM), TCDCA (50–500 μM), GDCA (100 μM) , TDCA (50–500 μM) and TLCA (100–500 μM) | No | UDCA and TUDCA (10–500 μM) | Chang et al. 2004 |
GCDCA (100 μM) | Not tested | Not tested | ||||
HuNoV/GII.3 | D, J, I | Duodenum HIE (D104 line) | GCDCA (500 μM) | Not tested | Not tested | Murakami et al. 2020 |
Jejunal HIE (J3 line) | GCDCA (500 μM) | Not tested | Not tested | |||
Jejunal HIE (J2 line) | GCA (500 μM), GDCA (500 μM), GCDCA (5–500 μM), TCA (500 μM), TDCA (500 μM), TCDCA (5–500 μM), TLCA (500 μM), TUDCA (500 μM), CA (500 μM), CDCA (100 μM), DCA (100 μM) and LCA (50 μM) | No | UDCA (500 μM) | |||
Ileum HIE (IL104 line) | GCDCA (500 μM) | Not tested | Not tested | |||
MuNoV/GV.1 | J, I, C | BV2 | GCDCA (500 μM) | No | TCA (500 μM), GCA (500 μM), CA (500 μM) and TDCA (500 μM) | Nelson et al. 2018 |
CMT93 | No | CDCA (100–200 μM) and DCA (100–200 μM) | CA (50–200 μM) and LCA (50–200 μM) | Grau et al. 2020 | ||
HuSaV/GI.1 | D, J | HuTu80 | CA (125 μM), GCA (1000 μM), GCDCA (500 μM) | No | DCA (71.4 μM) | Takagi et al. 2020 |
NEC8 | CA (250 μM), GCA (500 μM), GCDCA (200 μM) | No | DCA (20 μM) | |||
HuSaV/GI.2 | HuTu80 | GCA (1000 μM) | Not tested | No tested | ||
HuSaV/GII.3 | HuTu80 | CA (125 μM), GCA (1000 μM), GCDCA (500 μM) | No | DCA (71.4 μM) | ||
Rotavirus | J, I | MA104 | No | CDCA (100 μM) and DCA (100 μM) | CA (200 μM), UDCA (200 μM) and GCDCA (200 μM) | Kim and Chang 2011 |
Caco-2 | Not tested | CDCA (200 μM) | Not tested | |||
PEDV | J, I | Vero | GCDCA (100 μM) | Not tested | Not tested | Kim et al. 2017 |
Vero | CDCA (25–200 μM), GCDCA (50–200 μM), UDCA (50–200 μM) and DCA (50–200 μM) | No | No | Su et al. 2019 | ||
IPEC-DQ | CDCA (100–200 μM), GCDCA (25–200 μM), UDCA (50–200 μM) and DCA (50–200 μM) | No | No | |||
PDCoV | J, I | LLC-PK1 | No | CDCA (100 μM), LCA (12.5 μM) | GCDCA (100 μM), CA (100 μM), TCA (100 μM), DCA (50 μM), GDCA (100 μM), and TDCA (100 μM) | unpublished data |
IPEC-J2 | No | CDCA (100 μM), LCA (6 μM) | ||||