Table 2 Multi-pathogenicity of SAg toxins in human and animal diseases and the application in vaccines
From: Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins
| Diseases or vaccines | Associated SAgs (SE, SEl or TSST-1) |
|---|---|
| Animal diseases | |
| Bovine mastitis | SEC, TSST-1, SEG, SEN, SEO |
| Swine sepsis | SEB, TSST-1 |
| Arthritis and septicemia in poultry | SEA, SEB, SEC, SEQ |
| Human diseases | |
| Staphylococcal food poisoning | SEA~SEE, SEH, SE02 etc. |
| Soft tissue infection associated | TSST-1, SEB, SEC |
| Post respiratory viral infection | TSST-1, SEB, SEC, SElX |
| Purpura fulminans | TSST-1, SEB, SEC |
| Kawasaki-like diseases | TSST-1, SEB, SEC |
| Staphylococcal pneumonia | SEB, SEC, TSST-1, SElX |
| Staphylococcal infective endocarditis | SEC, TSST-1 |
| Staphylococcal sepsis | SEA, SEC, TSST-1 |
| Chronic rhinosinusitis | SEA to SEE, SEG to SEO |
| Atopic dermatitis | SEs, TSST-1 |
| Staphylococcal nonmenstrual TSS | TSST-1, SEB, SEC |
| Inflammatory arthritis | SEA, SEB, SEC, TSST-1 |
| Autoimmune diseases | SEB, SEC, SED, TSST-1 |
| Vaccines | |
| Vaccine for Saphylococcus infection | Mutant SEC, mutant TSST-1 |
| Vaccine for food poisoning | Mutant SEA |