Fig. 2From: The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significanceTherapeutic activation of remdesivir. This antiviral agent undergoes hydrolysis followed by several phosphorylation steps to form the antiviral metabolite nucleoside triphosphate. In human, the hydrolysis is achieved by CES1 but enzyme(s) for phosphorylation remains to be determinedBack to article page