Fig. 3
Diagrammatic presentation of carboxylesterases-based drug interactions with remdesivir. This virial agent is a substrate of CES1 but an irreversible inhibitor of CES2. Therefore, remdesivir catalytically impacts both enzymes (solid lines). In addition, many drugs and other xenobiotic compounds as well as disease mediators such as cytokines are established to regulate the expression of both enzymes. It is assumed that remdesivir has a potential of interacting with those factors (dotted lines)