The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance

Animal Diseases

Table 2 Efficacy of remdesivir in human clinical trials

Characteristic	^aBeigel	^bWang	^cGrein	^dGoldman	^eSpinner
Randomized controlled trial	Yes¹	Yes¹	No	Yes²	Yes²
Median time to recovery (Remdesivir)	10 days	21 days		11 day (10-day treatment)
Median time to recovery (Control)	15 days	23 days		10 day (5-day treatment)
Days to recovery (Remdesivir/control)	0.67	0.91		1.10
Clinical improvement (10-day)			68%		65%
Clinical improvement (5-day)					70%

^a Beigel et al. 2020; ^b Wang et al. 2020; ^c Grein et al. 2020; ^d Goldman et al. 2020; ^e Spinner et al. 2020
¹Randomized, double-blind, placebo-control clinical trials; ²randomized, open-label clinical trials