Author | Model | L/M dose | Route | Vial burden | Clinical improvement |
|---|
Pruijssers et al. 2020 | Mousea | 25 mg/kgb | sc | > 99 ↓ | ↑↑↑ |
Williamson et al. 2020 | R. macaques | 10/5 mg/kg/d | iv | 100 x ↓ | ↑↑↑↑ |
Ye et al. 2021 | Hamster | 15 mg/kg | ip | > 80% ↓ | ↑↑↑↑ |
Yuan et al. 2021 | Hamster | 15 mg/kg | ip | ~ 20% ↓ | ↑↑ |
- a Ces1c knockout; b Twice a day; R rhesus, sc subcutaneous injection, iv intravenous injection, ip intraperitoneal injection
