The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance

Animal Diseases

Table 6 Examples of remdesivir in treating other viral diseases

Human or animals	Virus	Viral family	Mortality	Viral replication	Clinical improvement	Cell culture
^aPig	PEDA¹	Coronaviridae				EC₅₀: 0.74 μM
^bHuman trial b	Ebola	Filoviridae	53%²
^cdefCat	FIP	Coronaviridae	83.9%³, 0%⁴	> 99%↓	↑↑↑↑
^gMacaque	Marburg	Filoviridae	17%	↓↓↓	↑↑↑
^hMacaque	MERS-CoV	Coronaviridae		↓↓↓↓	↑↑↑↑
ⁱMonkeyi	Nipah	Paramyxoviridae	0%	↓↓	↑↑↑↑
^jMousek	SARS-CoV	Coronaviridae		> 99%↓	> 50% ↑

¹Porcine epidemic diarrhea virus; ²No placebo control but worsening compared with ZMapp treatment group (positive control); ³No treatment control as this was naturally occurring infection; ⁴ Experimmental infection; ^3,4The parent drug of remdesivir (GS-441524) for the treatment
^aXie et al. 2021; ^bMulangu et al. 2019; ^cDickinson et al. 2020; ^dMurphy et al. 2018; ^ePedersen et al. 2019; ^fYin et al. 2021; ^gPorter et al. 2020; ^h de Wit et al. 2020; ⁱLo et al. 2019; ^jJohansen et al. 2020