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Fig. 7 | Animal Diseases

Fig. 7

From: African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1

Fig. 7

Schematic representation of ASFV MGF505-3R targeting TBK1 to inhibit IFN-β activity. MGF505-3R negatively regulates the IFN-β signaling axis by interacting with TBK1 and inhibiting the phosphorylation of TBK1 and IRF3, which may be achieved through the induction of autophagy. In addition, MGF505-3R inhibits the phosphorylation of IκBα, leading to reduced expression of early production of proinflammatory cytokines.

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Animal Diseases

ISSN: 2731-0442