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Fig. 10 | Animal Diseases

Fig. 10

From: Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus

Fig. 10

Altered mitochondrial gene expression of human brain microvascular endothelial cells (hBMECs). a quantification of gene expression by (RT-qPCR) showing the fold change increase or decrease for four mitochondrial genes expression NDUSF2, SDHA, CASP14 and UQCRFS1 within the infected hBMECs cells at 12 hpi compared to the control cells. statistical-significance analyzed by t-test * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001. b the GSEA running enrichment score for the suppression of ‘mitochondrial protein complex’ (NES = -2.4, padj = 0.025) enriched GO term and c its top downregulated genes. d indicates the GESA plot for negative running enrichment score of ‘mitochondrial gene expression’ (NES = -4.2, padj = 0.009) and e the top participating downregulated genes visualized in a heatmap. Black bars underneath the graph present the rank positions of genes from the gene set, the green line refers to the enrichment profile

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Animal Diseases

ISSN: 2731-0442