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Fig. 3 | Animal Diseases

Fig. 3

From: Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus

Fig. 3

Transcriptomic analysis of human brain microvascular endothelial cells (hBMECs) following infection with Influenza A virus. a Volcano plot of host genes differentially expressed at 12 hpi (padj < 0.05) and ± 2 log2FC change. Each dot represents a gene. The red, blue, green, and black dots represent the differentially expressed genes within the selected p-value (padj < 0.05) and log2FC ± 2, the p-value, the log2FC, and non-significant genes, respectively. b Heatmap of the top 20 genes induced in hBMECs treated with the A/WSN/33 compared to the control cells at 12 hpi (padj < 0.05), the genes are listed on the Y-axis. Each column represents one sample, the control cells are represented in three columns (replicates), and the same case is for the treatment. The overall number of differentially expressed genes is 5,500, among which 3,712 were up-regulated and 1,788 were down-regulated (|log2FC|≥ 1; padj < 0.05) A list of the differentially expressed genes is available in Supplementary file 2

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Animal Diseases

ISSN: 2731-0442