Fig. 1

Splicing of CD45 pre-mRNA results in generation of distinct isoforms. The figure demonstrates alternative splicing of CD45 isoforms in humans as information on cattle has not been published yet. CD45 pre-mRNA has 33 exons in humans, numbered from 1 to 33 in this figure. Differential splicing of exons 4/A, 5/B and 6/C generates at least six CD45 isoforms. The shortest CD45RO is generated by skipping all three differentially spliced exons. This figure was adapted from mini review published by Bio-Rad Laboratory (Bio-Rad Laboratories, Inc 2016), and modified/animated with https://biorender.com/