Fig. 3
From: CRISPR-Cas9 mediated phage therapy as an alternative to antibiotics
Genome editing by CRISPR-Cas system. CRISPR-Cas delivery can be made via transformation, transduction or conjugation. The outcome can be deleterious cell death due to massive DNA degradation or, the DNA break may be repaired while introducing some mutations. Catalytic domain inactive dCas9 can also silence a target gene by interfering with RNA polymerase function