Skip to main content

Table 2 The PK parameters after administration (20 mg/kg, IM) in PELF (Mean ± SD, n = 6)

From: The dose regimen formulation of doxycycline hydrochloride and florfenicol injection based on ex vivo pharmacokinetic-pharmacodynamic modeling against the Actinobacillus pleuropneumoniae in pigs

Parameters

Units

Single FF

FF of compound

Single DoxHcl

DoxHcl of compound

Healthy

Healthy

Diseased

Healthy

Healthy

Diseased

K12

h

0.11 ± 0.02

0.19 ± 0.008

0.18 ± 0.004

0.28 ± 0.01

0.18 ± 0.006

0.23 ± 0.008

K21

h

0.10 ± 0.002

0.15 ± 0.008

0.13 ± 0.004

0.15 ± 0.02

0.14 ± 0.01

0.12 ± 0.007

AUC0-24h

h·μg/mL

144.22 ± 1.98

172.75 ± 2.52

180.22 ± 3.13

133.26 ± 4.43

126.96 ± 3.70

169.82 ± 4.38

Tmax

h

3.14 ± 0.10

2.90 ± 0.05

3.07 ± 0.01

2.19 ± 0.05

2.72 ± 0.03

2.68 ± 0.03

Cmax

μg/mL

8.03 ± 0.20

8.87 ± 0.08

8.67 ± 0.07

7.68 ± 0.07

7.91 ± 0.09

7.99 ± 0.05

T1/2α

h

2.51 ± 0.31

1.72 ± 0.06

1.83 ± 0.03

1.34 ± 0.06

1.72 ± 0.06

1.66 ± 0.03

T1/2β

h

18.49 ± 0.47

17.74 ± 0.43

19.46 ± 0.42

19.56 ± 1.71

15.44 ± 1.01

24.44 ± 1.50

CL/F

L/kg/h

0.17 ± 0.09

0.12 ± 0.002

0.11 ± 0.002

0.15 ± 0.005

0.16 ± 0.005

0.12 ± 0.003

V1/F

L/kg

1.35 ± 0.15

1.11 ± 0.02

1.11 ± 0.02

1.21 ± 0.03

1.21 ± 0.02

1.16 ± 0.02

V2/F

L/kg

1.48 ± 0.13

1.36 ± 0.04

1.48 ± 0.03

2.29 ± 0.22

1.55 ± 0.11

2.26 ± 0.13

  1. The data were substituted into the first-order absorption two-compartment model in WinNonlin software to fit. K12 first-order rate constant of drug transport from the central compartment to the peripheral compartment, K21 first-order rate constant of drug transport from the peripheral chamber to the central chamber, AUC0-24h the area under the concentration-time curve, Cmax maximal drug concentration, Tmax time to reach Cmax, T1/2α the distribution half-life, T1/2β the elimination half-life, CL/F total body clearance as a function of bioavailability, V1/F distribution volume of the central chamber as a function of bioavailability, V2/F distribution volume of the peripheral chamber as a function of bioavailability