Parameters | Units | Single FF | FF of compound | Single DoxHcl | DoxHcl of compound | ||
---|---|---|---|---|---|---|---|
Healthy | Healthy | Diseased | Healthy | Healthy | Diseased | ||
K12 | h | 0.11 ± 0.02 | 0.19 ± 0.008 | 0.18 ± 0.004 | 0.28 ± 0.01 | 0.18 ± 0.006 | 0.23 ± 0.008 |
K21 | h | 0.10 ± 0.002 | 0.15 ± 0.008 | 0.13 ± 0.004 | 0.15 ± 0.02 | 0.14 ± 0.01 | 0.12 ± 0.007 |
AUC0-24h | h·μg/mL | 144.22 ± 1.98 | 172.75 ± 2.52 | 180.22 ± 3.13 | 133.26 ± 4.43 | 126.96 ± 3.70 | 169.82 ± 4.38 |
Tmax | h | 3.14 ± 0.10 | 2.90 ± 0.05 | 3.07 ± 0.01 | 2.19 ± 0.05 | 2.72 ± 0.03 | 2.68 ± 0.03 |
Cmax | μg/mL | 8.03 ± 0.20 | 8.87 ± 0.08 | 8.67 ± 0.07 | 7.68 ± 0.07 | 7.91 ± 0.09 | 7.99 ± 0.05 |
T1/2α | h | 2.51 ± 0.31 | 1.72 ± 0.06 | 1.83 ± 0.03 | 1.34 ± 0.06 | 1.72 ± 0.06 | 1.66 ± 0.03 |
T1/2β | h | 18.49 ± 0.47 | 17.74 ± 0.43 | 19.46 ± 0.42 | 19.56 ± 1.71 | 15.44 ± 1.01 | 24.44 ± 1.50 |
CL/F | L/kg/h | 0.17 ± 0.09 | 0.12 ± 0.002 | 0.11 ± 0.002 | 0.15 ± 0.005 | 0.16 ± 0.005 | 0.12 ± 0.003 |
V1/F | L/kg | 1.35 ± 0.15 | 1.11 ± 0.02 | 1.11 ± 0.02 | 1.21 ± 0.03 | 1.21 ± 0.02 | 1.16 ± 0.02 |
V2/F | L/kg | 1.48 ± 0.13 | 1.36 ± 0.04 | 1.48 ± 0.03 | 2.29 ± 0.22 | 1.55 ± 0.11 | 2.26 ± 0.13 |