Table 3 The PK-PD parameters for DoxHcl&FF against APP BW1 in PELF

C_max/MIC

–

4.44 ± 0.04

4.34 ± 0.04

3.96 ± 0.05

4.00 ± 0.03

AUC_0-24h/MIC

h

86.38 ± 1.26

90.11 ± 1.57

63.48 ± 1.85

84.91 ± 2.19

C_max/MBC

–

2.22 ± 0.02

2.17 ± 0.02

1.98 ± 0.03

2.00 ± 0.02

AUC_0-24h/MBC

h

43.19 ± 0.63

45.06 ± 0.79

31.74 ± 0.93

42.46 ± 1.10

C_max/MPC

–

1.10 ± 0.01

1.08 ± 0.01

0.99 ± 0.01

1.00 ± 0.01

AUC_0-24h/MPC

h

21.59 ± 0.32

22.53 ± 0.39

15.87 ± 0.46

21.23 ± 0.55