Fig. 2

A Location of antigen epitopes in animal CoV genomes. B Distribution of antigen epitopes in the S1/S2 junction of animal CoV S proteins. The predicted tertiary structures of the S region of PEDV (PDB ID: 6VV5), BCoV (PDB ID: 6NZK), and MHV (PDB ID: 3JCL) were modeled using the open-source modeling server SWISS-MODEL (https://swissmodel.expasy.org/) from the Swiss Institute of Bioinformatics (Biasini et al. 2014). Illustrations of these modeled tertiary structures were obtained using the python-based molecular viewer PyMOL (The PyMOL Molecular Graphics System, V. 1.7.4 Schrödinger, LLC)