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Table 1 Application of animal CoV antigen epitopes

From: Antigen epitopes of animal coronaviruses: a mini-review

Coronaviruses (protein)

Sequence

Application

References

PEDV (S-COE)

Y748SNIGVCK755

Vaccine: production of neutralizing antibody (used HBcAg as vector)

Gillam and Zhang 2018

PEDV (S)

T592SLLASACTIDLFGYP607

Vaccine: production of neutralizing antibody

Sun et al. 2019

FIPV (S)

N621NYLTFNKFCLSLSPVGANC640

Vaccine: induce Th1 activity

Takano et al. 2014

FIPV (M)

V81YGIKMLIMWLLWPIVLALT100

Vaccine: induce Th1 activity

Takano et al. 2014

FIPV (N)

G81QRKELPERWFFYFLGTGPH100

Vaccine: induce Th1 activity

Satoh et al. 2011

IBV (S)

S413RIQTATDP421,

517RNATGSQP525,

G45AYAVVNV52,

S413RIQTATQP421

Vaccine: stimulate CD8 + T-cell proliferation and IFN-γ secretion

Tan et al. 2016

TGEV (S)

TGEV S-A site (533–705)

Vaccine: increase the Th1 and Th2 cytokine levels

Gebauer et al. 1991

MHV (S: S1/S2 junction)

L766TTFEPFTVSIVNDS780

Vaccine: induces CD4 T-cell response in mice

Khanolkar et al. 2010

PEDV (S-COE)

T592SLLASACTIDLFGYP607

Diagnosis: mABs 4D8F10 and 6F3E3 recognize the COE, and highly conserved

Sun et al. 2019

TGEV (S)

T592SLLASACTIDLFGYP607

Diagnosis: highly conserved

Gebauer et al. 1991

MHV (N)

I24LKKTTWADQTERGL38

R357FDSTLPGFETIMKVL372

Diagnosis (ELISA): more sensitive than the commercial tests

Asano et al. 2011

IBV (S)

TGEV (S1: 166–247, S1: 501–515, S2: 8–30)

Diagnosis (ELISA): more sensitive and specific than the commercial tests

Ding et al. 2015