Fig. 3
From: Classical bovine spongiform encephalopathy and chronic wasting disease: two sides of the prion coin
Molecular characteristics of PrPres in different species infected with either BSE or CWD. Differentiation of the various forms of bovine spongiform encephalopathy (BSE) – including classical (Lane 1) and both L- and H-type atypical BSE (Lanes 2 and 3, respectively) – is readily accomplished by comparing the relative molecular weights, weight range, and ratios of the di-, mono-, and unglycosylated PrPres bands (Porcario et al. 2011). These profiles are distinct from BSE isolated in experimental studies of BSE in red deer (Lane 4) and sheep (Lane 5) (Martin et al. 2009). Isolates of chronic wasting disease (CWD) prions from experimentally infected sheep (lane 6) (Hamir et al. 2006b) and naturally infected mule deer from North America (NA, Lane 8) (Williams 2005) are quite similar, though distinct from isolates from both experimentally inoculated cattle (Lane 7) (Hamir et al. 2005) and a novel isolate from a naturally infected moose in Scandinavia (Sc, Lane 9) (Sun et al. 2023). Relative molecular weight and glycosylation profiles may vary subtly across brain regions and host Prnp genotypic background