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Fig. 3 | Animal Diseases

Fig. 3

From: Preparation of anti-canine interleukin-31 receptor alpha polyclonal antibody and evaluation of its therapeutic effect in canine atopic dermatitis

Fig. 3

Therapeutic effect of anti-IL-31RA pAbs. A CADESI-4 method to assess the severity of skin injury in CAD model dogs after treatment with anti-IL-31RA pAbs. ** P < 0.01. B Pruritus score from the pVAS evaluation. ** P < 0.01. C A Vernier caliper was employed to detect the inguinal thickness of the dogs. **** P < 0.0001 vs. negative control. D H&E staining of the inguinal sections was performed following the last application of the anti-IL-31RA pAbs. Scale bars = 100 μm. **** P < 0.0001 vs. negative control. The black arrows indicate inflammatory cells. A semiquantitative method was used to assess the severity of skin tissue inflammation. Saline treatment was the negative control group. The dogs treated with the antibody obtained by immunizing them with BSA were the negative antibody control group. Anti-IL-31 pAb was the positive antibody control. Data are expressed as the means ± SDs

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Animal Diseases

ISSN: 2731-0442