Table 2 Properties of tilmicosin suspension at different stages (Mean ± SD, N = 3)
Evaluation index | Laboratory research | Small-scale production | Pilot production |
|---|---|---|---|
Size (μm) | 0.73 ± 0.21 | 2.87 ± 0.71 | 2.64 ± 0.55 |
Appearance | Light yellow milky | Light yellow milky | Light yellow milky |
Content (%) | 5.34 ± 0.12 | 5.14 ± 0.18 | 4.95 ± 0.31 |
Sedimentation coefficient | 0.97 ± 0.08 | 0.95 ± 0.03 | 0.94 ± 0.05 |
Dispersibility | Excellent | Excellent | Excellent |
Related substance (%) | < 3% | < 3% | < 3% |