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Table 3 Strong degradation test of tilmicosin suspension

From: Hot melt emulsification shear method for solid lipid-based suspension: from laboratory-scale to pilot-scale production

Factors

Degradation rate (%)

Recovery rate (%)

Degradation condition

High temperature

9.6 ± 0.04

97.55 ± 0.03

80℃, 96 h

Strong light

6.54 ± 0.02

97.34 ± 0.06

8400 lx, 96 h

Strong oxidation

5.7 ± 0.02

97.05 ± 0.04

0.1%, 4 h

Strong acid

11.7 ± 0.02

99.1 ± 0.02

4 mol/L, 60 h

Strong alkali

12 ± 0.03

96.1 ± 0.02

1 mol/L, 4 h

  1. Degradation conditions mean that the drug will have certain degradation and recovery rates under this condition