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Table 4 The influence factor test of tilmicosin suspension (Mean ± SD, n = 3)

From: Hot melt emulsification shear method for solid lipid-based suspension: from laboratory-scale to pilot-scale production

Factors

Evaluation index

No

Stabiliter

Small-test

Product

 

Polit

Product

 

0 d

5 d

0 d

5 d

10 d

0 d

5 d

10 d

High

Properties

-

-

LYM

LYM

LYM

LYM

LYM

LYM

temperature

Content (%)

5.21 ± 0.14

4.03 ± 0.15

5.16 ± 0.07

5.10 ± 0.15

5.07 ± 0.04

5.06 ± 0.21

5.00 ± 0.14

4.95 ± 0.23

Size (μm)

-

-

2.01 ± 0.05

2.68 ± 0.06

2.63 ± 0.10

2.75 ± 0.05

2.57 ± 0.07

2.64 ± 0.15

SC

-

-

1

1

1

1

1

1

Dispersibility

-

-

Excellent

Excellent

Excellent

Excellent

Excellent

Excellent

RS (%)

 > 3%

 > 3%

 < 3%

 < 3%

 < 3%

 < 3%

 < 3%

 < 3%

High

Properties

-

-

LYM

LYM

LYM

LYM

LYM

LYM

humility

Content (%)

5.21 ± 0.14

4.08 ± 0.64

5.16 ± 0.07

5.17 ± 0.1

5.12 ± 0.13

5.06 ± 0.21

5.04 ± 0.17

5.04 ± 0.34

Size (μm)

-

-

2.03 ± 0.02

1.86 ± 0.11

1.96 ± 0.01

2.91 ± 0.01

3.05 ± 0.13

3.10 ± 0.09

SC

-

-

1

1

1

1

1

1

Dispersibility

-

-

Excellent

Excellent

Excellent

Excellent

Excellent

Excellent

RS (%)

 > 3%

 > 3%

 < 3%

 < 3%

 < 3%

 < 3%

 < 3%

 < 3%

High

Properties

-

-

LYM

LYM

LYM

LYM

LYM

LYM

light

Content (%)

5.21 ± 0.14

4.14 ± 0.41

5.16 ± 0.07

5.12 ± 0.12

5.13 ± 0.37

5.06 ± 0.21

4.99 ± 0.14

5.00 ± 0.17

Size (μm)

-

-

2.00 ± 0.03

2.29 ± 0.08

1.96 ± 0.10

2.70 ± 0.03

2.91 ± 0.23

3.04 ± 0.21

SC

-

-

1

1

1

1

1

1

Dispersibility

-

-

Excellent

Excellent

Excellent

Excellent

Excellent

Excellent

RS (%)

 > 3%

 > 3%

 < 3%

 < 3%

 < 3%

 < 3%

 < 3%

 < 3%

  1. No stabilizer indicates that no stabilizer is added to the product. Three batches of samples were taken at 0 days, and the content was tested only once (in triplicate), so the initial content was consistent. The samples in the table were tested in triplicate. High temperature: The temperature is 60℃
  2. Abbreviations: LYM light yellow milky, SC sedimentation coefficient, RS related substance