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Fig. 4 | Animal Diseases

Fig. 4

From: Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice

Fig. 4

Understanding the BCG efficacy downfall mechanism in depressed mice. A-C mRNA expression of IL-10, IL-17 and IL-5 was quantified by qRT‒PCR. D Gating of Treg cells. E The percentage of regulatory T cells was calculated for all four groups in comparison with the control group. F The CD11b+ cells were segregated and gated according to the Ly6G+ and Ly6C+ antibodies depicted in the images. G, H The percentage of granulocytic-MDSCs (Ly6C−Ly6G+) and monocytic MDSCs (Ly6C+Ly6G.−) found in splenocytes in different sets of mice. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001; ****, p ≤ 0.0001 (one-way ANOVA). Data are representative of three independent experiments with three biological replicates (mean ± SEM)

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Animal Diseases

ISSN: 2731-0442