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Citation: Animal Diseases 2024 4:13
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Anticoccidial activity of essential oils containing eugenol against Eimeria tenella in broiler chickens
The development of alternative therapies to treat chicken coccidiosis has become a hot topic because of the widespread use of conventional medicines. This study aimed to investigate the effectiveness of eugeno...
Citation: Animal Diseases 2024 4:12 -
Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region
Zoonotic hookworm infections remain a significant public health problem, causing nearly 500 million cases globally and approximately four million disability-adjusted life years lost annually. More than one-fif...
Citation: Animal Diseases 2024 4:11 -
The phosphoethanolamine transferase PetL of Pasteurella multocida is associated with colistin resistance
The rapid emergence and spread of colistin-resistant gram-negative bacteria has raised worldwide public health concerns, and phosphoethanolamine (PEtn) transferase modification-mediated colistin resistance has...
Citation: Animal Diseases 2024 4:10 -
Two nanobody-based immunoassays to differentiate antibodies against genotype 1 and 2 porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes significant economic loss to the global pig industry. Genotype 1 and 2 PRRSV (PRRSV-1 and -2) infections have been reported in China...
Citation: Animal Diseases 2024 4:9 -
Preparation and interaction mechanism analysis of single-chain fragment variables against phenylethanolamine A
This is the first report on the screening, expression, and recognition mechanism analysis of single-chain fragment variable (scFv) against phenylethanolamine A (PEAA), a newly emerged β-adrenergic agonist ille...
Citation: Animal Diseases 2024 4:8 -
Characterization and genomics analysis of phage PGX1 against multidrug-resistant enterotoxigenic E. coli with in vivo and in vitro efficacy assessment
Enterotoxigenic E. coli is one of the bacterial pathogens contributing to the global resistance crisis in public health and animal husbandry. The problem of antibiotic resistance is becoming more and more serious...
Citation: Animal Diseases 2024 4:7 -
Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi: a scoping review
Trypanosoma cruzi is the etiologic agent of Chagas disease. This flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family (kn...
Citation: Animal Diseases 2024 4:6 -
Isolation of a feline-derived feline panleukopenia virus with an A300P substitution in the VP2 protein and confirmation of its pathogenicity in dogs
Feline panleukopenia virus (FPV) is a single-stranded DNA virus that can infect cats and cause feline panleukopenia, which is a highly contagious and fatal disease in felines. The sequence of FPV is highly var...
Citation: Animal Diseases 2024 4:5 -
Isolation of four carbapenem-resistant gram-negative species from a single fly
The widespread occurrence of carbapenem-resistant organisms has garnered significant public attention. Arthropods, including flies, are important vectors of multidrug-resistant bacteria. In this study, we repo...
Citation: Animal Diseases 2024 4:4 -
Identification of novel serological agents for porcine deltacoronavirus infection based on the immunogenic accessory protein NS6
Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic CoV that causes severe vomiting, diarrhea and dehydration in suckling piglets, leading to economic losses in the swine industry. There is a great ne...
Citation: Animal Diseases 2024 4:3 -
Biomedical knowledge graph construction of Sus scrofa and its application in anti-PRRSV traditional Chinese medicine discovery
As a new data management paradigm, knowledge graphs can integrate multiple data sources and achieve quick responses, reasoning and better predictions in drug discovery. Characterized by powerful contagion and ...
Citation: Animal Diseases 2024 4:2 -
Molecular characterization of canine parvovirus type 2 (CPV2) reveals a high prevalence of the CPV2c genotype among dogs suffering from diarrhea
Canine parvovirus 2 (CPV-2) is a highly contagious virus in dogs that typically causes hemorrhagic enteritis and a high mortality rate in unvaccinated puppies. The genetic variability and antigenic diversity o...
Citation: Animal Diseases 2024 4:1 -
Chronic social defeat stress-induced depression reduces BCG efficacy by promoting regulatory T-cell levels in mice
Despite the initial successes of the Bacillus Calmette-Guerin (BCG) vaccine in children, its efficacy against tuberculosis is highly variable. There is a lack of understanding about how mental conditions influ...
Citation: Animal Diseases 2023 3:40 -
Spatiotemporal distribution of foot-and-mouth disease in Nepal between 2019 and 2021
Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed livestock. It is caused by the FMD virus (FMDV), which has seven distinct serotypes (O, A, C, SAT I, SAT II, SAT III, a...
Citation: Animal Diseases 2023 3:39 -
The generation of hemagglutinin monoclonal antibodies against H9N2 influenza virus
H9N2 avian influenza viruses (AIVs) are widely distributed, causing continuous outbreaks in poultry and sporadic infections in humans. Vaccination is the primary method used to prevent and control H9N2 AIV inf...
Citation: Animal Diseases 2023 3:38 -
Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum
Chronic kidney disease is commonly diagnosed in dogs, and clinical signs may be aggravated when infected agents are involved. In this case report, 33 dogs with chronic kidney disease were clinically evaluated ...
Citation: Animal Diseases 2023 3:37 -
Hot melt emulsification shear method for solid lipid-based suspension: from laboratory-scale to pilot-scale production
The clinical application of solid lipid particles (SLPs) is hampered due to the need for advanced nano/micro-suspension production technology. This research aims to establish a pilot-scale production line empl...
Citation: Animal Diseases 2023 3:36 -
Chinese herbal extracts with antiviral activity: evaluation, mechanisms, and potential for preventing PRV, PEDV and PRRSV infections
The rapid expansion of large-scale pig farming has brought about a surge in viral diseases with high morbidity rates and diverse manifestations. This widespread occurrence of multiple viral diseases in pig far...
Citation: Animal Diseases 2023 3:35 -
Management practices and technologies for efficient biological sample collection from domestic animals with special reference to Indian field conditions
Management strategies and the use of advanced technologies are equally important for determining the sample number and sampling frame for successful field sampling for animal disease prevalence studies. The qu...
Citation: Animal Diseases 2023 3:34 -
Allelic functional variation of FimH among Salmonella enterica subspecies
Salmonella enterica has a wide diversity, with numerous serovars belonging to six different subspecies with dynamic animal-host tropism. The FimH protein is the adhesin mediating binding to various cells, and sli...
Citation: Animal Diseases 2023 3:33 -
Reference intervals for hematology, plasma biochemistry, and bone mineral density in captive Ceratophrys cranwelli (Anura: Ceratophryidae)
Hematology, plasma biochemistry, body composition, and bone mineral density (BMD) were analyzed for 30 captive Ceratophrys cranwelli (C. cranwelli) to establish the reference intervals. There was no significant d...
Citation: Animal Diseases 2023 3:32 -
Are dogs not susceptible to retroviral infections?
Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments...
Citation: Animal Diseases 2023 3:31 -
Monocyte and macrophage function in respiratory viral infections
Pulmonary macrophages, such as tissue-resident alveolar and interstitial macrophages and recruited monocyte-derived macrophages, are the major macrophages present in the lungs during homeostasis and diseased c...
Citation: Animal Diseases 2023 3:30 -
Establishment and characterization of a canine chondrosarcoma cell line: Mango
In the global progress of bone tumor research, established stable and long-lasting transgenic chondrosarcoma (CSA) cell lines are rare, mainly of murine and human origin, while the establishment of canine CSA ...
Citation: Animal Diseases 2023 3:29 -
Toxoplasma gondii adhesion and apoptosis of chicken erythrocytes
Toxoplasma gondii is thought to infect all nucleated cells in warm-blooded animals, including poultry, mammals, and humans. However, it is unclear whether T. gondii can infect chicken erythrocytes due to the nucl...
Citation: Animal Diseases 2023 3:28 -
Non-O1/O139 Vibrio cholerae causes severe intestinal disease in bullfrogs (Rana catesbeiana)
Bullfrogs (Rana catesbeiana) are amphibians with high economic value, but in recent years, bullfrog farming has encountered serious threats of bacterial diseases, and the “bullfrog economy” is facing a continuous...
Citation: Animal Diseases 2023 3:27 -
Preparation of anti-canine interleukin-31 receptor alpha polyclonal antibody and evaluation of its therapeutic effect in canine atopic dermatitis
Canine atopic dermatitis (CAD) is a prevalent genetically susceptible inflammatory and pruritic allergic skin condition affecting not only the health of dogs but also the quality of life of their owners. Inter...
Citation: Animal Diseases 2023 3:26 -
Mathematical modeling of trypanosomiasis control strategies in communities where human, cattle and wildlife interact
Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over. With the disease targeted for elimination by 2030, assessing the impact of control st...
Citation: Animal Diseases 2023 3:25 -
Classical bovine spongiform encephalopathy and chronic wasting disease: two sides of the prion coin
Transmissible spongiform encephalopathies (TSEs) are a group of progressive and ultimately fatal neurologic diseases of man and animals, all resulting from the propagated misfolding of the host’s normal cellul...
Citation: Animal Diseases 2023 3:24 -
Gut microbiota as a target in the bone health of livestock and poultry: roles of short-chain fatty acids
The regulation and maintenance of bone metabolic homeostasis are crucial for animal skeletal health. It has been established that structural alterations in the gut microbiota and ecological dysbiosis are close...
Citation: Animal Diseases 2023 3:23 -
Selenium nanoparticles reduce oxidative stress-induced cardiomyocyte apoptosis in ascites syndrome in broiler chickens via the ATF6-DR5 signaling pathway
Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndr...
Citation: Animal Diseases 2023 3:22 -
MicroRNA transcriptome analysis of chicken embryo fibroblast cells infected with Newcastle disease virus variants
Variations in the pathogenicity of Newcastle disease virus (NDV), the agent causing Newcastle disease, are associated with variants of different virulence. A few studies have characterized the expression of mi...
Citation: Animal Diseases 2023 3:21 -
Risk factors associated with Salmonella in dairy cattle farms in Henan and Hubei provinces, China
A cross-sectional study was conducted to evaluate the risk factors associated with the Salmonella infection status of dairy herds in Henan and Hubei provinces, China. Herds were assigned a Salmonella status based...
Citation: Animal Diseases 2023 3:20 -
Avibacterium paragallinarum: an emerging birds pathogen in Qinling wildlife conservation center, China
The bacterium Avibacterium paragallinarum, previously known as Haemophilus paragallinarum, is responsible for causing infectious coryza (IC) in chickens and other avian species. In this case report, an outbreak o...
Citation: Animal Diseases 2023 3:19 -
Key roles of amylopectin synthesis and degradation enzymes in the establishment and reactivation of chronic toxoplasmosis
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite with a wide range of hosts, including humans and many warm-blooded animals. The parasite exists in two interconvertible forms, namely tachyzoite...
Citation: Animal Diseases 2023 3:18 -
Essential role of ATG7 in LPS-induced endometrial inflammatory injury in goats
The economic losses caused by uterine infections in ruminants have received increasing attention. Autophagy-related 7 (ATG7) has been demonstrated to be capable of regulating apoptosis, but surprisingly, ATG7 can...
Citation: Animal Diseases 2023 3:17 -
Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism
Antibiotics are widely used to treat various diseases. However, growing evidence indicates that antibiotic therapy in human life increases the incidence of inflammatory bowel disease (IBD). Therefore, we need ...
Citation: Animal Diseases 2023 3:16 -
Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism
Rabies is an ancient disease. Two centuries since Pasteur, fundamental progress occurred in virology, vaccinology, and diagnostics—and an understanding of pathobiology and epizootiology of rabies in testament ...
Citation: Animal Diseases 2023 3:15 -
Antigen epitopes of animal coronaviruses: a mini-review
Coronaviruses are widespread in nature and can infect mammals and poultry, making them a public health concern. Globally, prevention and control of emerging and re-emerging animal coronaviruses is a great chal...
Citation: Animal Diseases 2023 3:14 -
Enzootic epidemiology of Brucella in livestock in central Gansu Province after the National Brucellosis Prevention and Control Plan
Brucellosis remains one of the most common zoonoses spread worldwide, inducing enormous economic losses to the livestock industry and posing serious health threats to humans. Brucellosis re-emerged in China in...
Citation: Animal Diseases 2023 3:13 -
Roles of host proteases in the entry of SARS-CoV-2
The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is divided with S1 and S2 regi...
Citation: Animal Diseases 2023 3:12 -
Study on incidence of lamb morbidity and mortality and associated risk factors in the mixed crop-livestock production system of Gewata District, Kaffa zone, southwestern Ethiopia
Lamb morbidity and mortality cause significant loss in a smallholder production system. A longitudinal prospective survey was conducted on 408 randomly selected farmers located in six purposefully selected keb...
Citation: Animal Diseases 2023 3:11 -
Taenia solium taeniasis and cysticercosis: extinction or outbreak
Taenia solium taeniasis and cysticercosis are neglected zoonotic diseases that affect human health and economies of developing countries. In this work, we formulate and analyze deterministic and continuous time M...
Citation: Animal Diseases 2023 3:10 -
Correction: Antibody seropositivity and endemicity of chikungunya and Zika viruses in Nigeria
Citation: Animal Diseases 2023 3:9 -
Evaluation and application of a milk antibody ELISA for assessing the prevalence and incidence of bovine tuberculosis in dairy herds in Hubei Province, China
Bovine tuberculosis (bTB) is a chronic zoonotic disease that is endemic in China. Current in-vitro tests for bTB are mainly based on blood assays. Collection of samples results in some stress to the sampled cattl...
Citation: Animal Diseases 2023 3:8 -
Antibody seropositivity and endemicity of chikungunya and Zika viruses in Nigeria
Mosquito-borne infections are of global health concern because of their rapid spread and upsurge, which creates a risk for coinfections. chikungunya virus (CHIKV), an arbovirus disease transmitted by Aedes aegypt...
Citation: Animal Diseases 2023 3:7 -
Case report: Diagnosis and treatment of a chinchilla’s old radius and ulna fracture
The cortex of the limb bones of chinchillas is very thin and brittle, so it is prone to fractures of the limb bones, among which fractures of the tibia, radius and ulna are the most frequent types. When a chin...
Citation: Animal Diseases 2023 3:6 -
Involvement of 2′-5′ oligoadenylate synthetase-like protein in the survival of Mycobacterium tuberculosis avirulent strain in macrophages
Mycobacterium tuberculosis (M. tuberculosis) can replicate in the macrophage by interfering with many host protein functions. While it is far from known these host proteins for controlling M. tuberculosis infecti...
Citation: Animal Diseases 2023 3:5 -
CRISPR-Cas9 mediated phage therapy as an alternative to antibiotics
Inappropriate use of antibiotics is globally creating public health hazards associated with antibiotic resistance. Bacteria often acquire antibiotic resistance by altering their genes through mutation or acqui...
Citation: Animal Diseases 2023 3:4
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Affiliated with
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Huazhong Agricultural University (HZAU) is a national key university of “Project 211” directly under the Ministry of Education. HZAU enjoys a history of 120 years, covers an area of 495 hectares, and consists of 18 colleges and departments. Featuring life science, HZAU also gives much emphasis on the rational disciplinary construction of agriculture, sciences, engineering, arts, law, economics, and management.